{"id":1072,"date":"2021-04-01T20:01:43","date_gmt":"2021-04-02T01:01:43","guid":{"rendered":"https:\/\/sites.imsa.edu\/hadron\/?p=1072"},"modified":"2021-04-01T20:01:43","modified_gmt":"2021-04-02T01:01:43","slug":"ancient-viruses-frozen-in-permafrost","status":"publish","type":"post","link":"https:\/\/sites.imsa.edu\/hadron\/2021\/04\/01\/ancient-viruses-frozen-in-permafrost\/","title":{"rendered":"Ancient Viruses Frozen in Permafrost"},"content":{"rendered":"<p>Written by Margaret Wei<\/p>\n<p><b>Background<\/b><\/p>\n<p><span style=\"font-weight: 400\">As carbon emissions increase annually, so too does the average world temperature. This is a result of the greenhouse effect as the emissions create heat, in which the sun rays are trapped in the earth\u2019s atmosphere, preventing the accumulated heat from being released. The increase in temperature is a concern to scientists because viruses that were trapped in frozen arctic permafrost, preserved since the Ice Age thousands of years ago, can potentially make contact with humans (Mohan, 2014). Viruses enter host cells by penetrating through the cellular membranes, attaching to receptors, changing its viral proteins. In the end, the virus transfers its viral genomes inside host cells. Scientists are most concerned about the undiscovered capabilities of these viruses.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>Discovery of the <\/b><b><i>Mollivirus sibericum<\/i><\/b><\/p>\n<p><span style=\"font-weight: 400\">The presence of the frozen viruses was first made known to the public in 2015; researchers Chantal Abergel and Jean-Michel Claverie of the French Centre National de la Recherche Scientifique uncovered the <\/span><i><span style=\"font-weight: 400\">Mollivirus sibericum<\/span><\/i><span style=\"font-weight: 400\"> in 30,000 year old permafrost, and as they put it in their paper, &#8220;The fact that two different viruses retain their infectivity in prehistorical permafrost layers should be of concern in a context of global warming\u201d (Wei, 2018).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">The microbe, described in the Proceedings of the National Academy of Sciences, appears to belong to a family of mega-viruses that exclusively infect amoebas, but its revival stands as &#8220;a proof of principle that we could eventually resurrect active infectious viruses from different periods,&#8221; said the study&#8217;s lead author, Jean-Michel Claverie (Mohan, 2014). The <\/span><i><span style=\"font-weight: 400\">Mollivirus sibericum<\/span><\/i><span style=\"font-weight: 400\"> was visibly large under the microscope and it consisted of a significant amount of genetic material.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">A study in Alaskan permafrost was undertaken to learn more about the discovery and the potential impacts of global warming and permafrost thawing on metabolic pathways (Mooney, 2015). The researchers tested soils before and after thawing and found a rapid increase in activity after thawing due to the decomposition of soil organic matter. The thawing of permafrost leads to increased microbial activity and, as a result, increased emissions of greenhouse gases such as CO<\/span><span style=\"font-weight: 400\">2<\/span><span style=\"font-weight: 400\">, CH<\/span><span style=\"font-weight: 400\">4<\/span><span style=\"font-weight: 400\">, and N<\/span><span style=\"font-weight: 400\">2<\/span><span style=\"font-weight: 400\">O, which were previously trapped within (Collins, 2019). The increased methane emission resulted in a tenfold increase in the number of methanogenic archaea, as well as large changes in the composition and operations of archaeal communities.<\/span><\/p>\n<p><b>Conclusion and Further Research<\/b><\/p>\n<p><span style=\"font-weight: 400\">Although this was a groundbreaking discovery, this does not signify that it is likely for these viruses to use humans as their host organism. \u201cAll viruses tend to be very specific about their host species, so there is essentially no chance that the viruses they discovered will have any impact on human health,\u201d stated Grant McFadden, a professor of molecular genetics and microbiology at the University of Florida and the former president of the American Society for Virology (Mooney, 2015). In addition, more research needs to be done in order to rule out the possibility that they could survive this long-term freezing and still infect their host, though it is questionable that they can last tens of thousands of years without a host.<\/span><\/p>\n<p><span style=\"font-weight: 400\">A more pressing issue of the impact of global warming on pathology is the threat of the spread of vector-borne diseases, much less the melting permafrost. Organisms tend to migrate and follow unusual travel behavior in an environment where the temperature and climate are unstable. McFadden states that, \u201cthe wider global spread of insect vectors (particularly mosquitoes) and the viral pathogens they carry, compared to the real threat caused by ever increasing geographic ranges of vector-borne diseases like Dengue and Chikungunya viruses, the threat to human health of re-animated viruses from thawing permafrost is vanishingly small\u201d (Wei, 2018).<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400\">References and Sources<\/span><\/p>\n<p><span style=\"font-weight: 400\">Geoffrey Mohan. (2014). Ancient, frozen mega-virus is revived; If 30,000 years in Siberian permafrost didn\u2019t kill it, human pathogens may lurk too, researchers say. The Los Angeles Times.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400\">Margesin, R., &amp; Collins, T. (2019). Microbial ecology of the cryosphere (glacial and permafrost habitats): current knowledge. Applied Microbiology and Biotechnology, 103(6), 2537\u20132549. https:\/\/doi.org\/10.1007\/s00253-019-09631-3<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400\">Chris Mooney. (2015). Why you shouldn\u2019t freak out about ancient \u201cFrankenviruses\u201d emerging from Arctic permafrost: Of all the pandemic health risks we face, ancient Arctic viruses rank pretty low, say scientists. In Washington Post \u2013 Blogs. WP Company LLC d\/b\/a The Washington Post.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400\">Wei, SP, Cui, HP, Zhu, YH, Lu, ZQ, Pang, SJ, Zhang, S, Dong, HL, Su, X: Shifts of methanogenic communities in response to permafrost thaw results in rising methane emissions and soil property changes. vol. 22, issue 3, pp. 447-459. Extremophiles (2018)<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Written by Margaret Wei Background As carbon emissions increase annually, so too does the average world temperature. This is a result of the greenhouse effect as the emissions create heat, in which the sun rays are trapped in the earth\u2019s atmosphere, preventing the accumulated heat<\/p>\n","protected":false},"author":586,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-1072","post","type-post","status-publish","format-standard","hentry","category-biology"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/posts\/1072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/users\/586"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/comments?post=1072"}],"version-history":[{"count":1,"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/posts\/1072\/revisions"}],"predecessor-version":[{"id":1073,"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/posts\/1072\/revisions\/1073"}],"wp:attachment":[{"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/media?parent=1072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/categories?post=1072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.imsa.edu\/hadron\/wp-json\/wp\/v2\/tags?post=1072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}